Comprehensive Guide to Electrospray Ionization (ESI) in Modern Mass Spectrometry
Summary: Electrospray Ionization (ESI) is a key technique in LC-MS, enabling the gentle ionization of thermally labile and polar compounds, particularly useful for analyzing biomolecules like small molecules & proteins. Innovations such as the pneumatically assisted nebulizer have stabilized the process and optimized it for liquid chromatography. ESI mechanisms include the Ion Evaporation Model (IEM) […]
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