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Comprehensive Guide to Electrospray Ionization (ESI) in Modern Mass Spectrometry

Summary: Electrospray Ionization (ESI) is a key technique in LC-MS, enabling the gentle ionization of thermally labile and polar compounds, particularly useful for analyzing biomolecules like small molecules & proteins. Innovations such as the pneumatically assisted nebulizer have stabilized the process and optimized it for liquid chromatography. ESI mechanisms include the Ion Evaporation Model (IEM) […]

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Featured Image Blog Method Development | A Comprehensive Analysis of the Fundamental Differences Between Methanol and Ethanol

Method Development | A Comprehensive Analysis of the Fundamental Differences Between Methanol and Ethanol

For those pressed for time, we’ve condensed the essence of methanol and ethanol distinctions into a concise summary, tailored to maximize your valuable reading experience. Summary: Methanol and acetonitrile are commonly regarded as cornerstone organic solvents in the formulation of mobile phases for reversed-phase liquid chromatography (RPLC), with each occupying a pivotal role in the

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Determination of L-carnitine in the foods for export HPLC method and HPLC-MS/MS method

1. Scope This standard specifies the determination of L-carnitine in the foods for export by HPLC and HPLC-MS/MS. This standard applies to the L-carnitine detection in milk powder, beverages, and other foods. Note: lf the D-carnitine is present in the sample, the result of HPLC-MS/MS method is the sum of L-carnitine and D-carnitine. 2. Normative

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Feature Image of Determination of semicarbazide in flour and its products LCMS method

Determination of semicarbazide in flour and its products LC-MS/MS method

1. Scope This standard specifies the method of determination of semicarbazide in flour and its products for export by LC-MS/MS methodThis standard applies to the determination of semicarbazide in wheat flour, fry powder, fine-dried noodles, bread crumbs, noodles, steamed bread, Fried flour, egg yolk pie, biscuits, instant noodles, bread, wheat flour, and its products for

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Exploring the Chemistry Behind SPE Cartridges

Solid Phase Extraction (SPE) cartridges are instrumental in selectively extracting target analytes from complex sample matrices while eliminating interfering substances. The choice of sorbent material is pivotal, dictating the selectivity, efficiency, and efficacy of the extraction process. Here, we delve into a comprehensive analysis of SPE sorbents and their indispensable role in sample preparation. Overview

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Evolution of Solid Phase Extraction (SPE) Cartridges: Key Milestones in Analytical Chemistry

The evolution of Solid Phase Extraction (SPE) cartridges stands as a testament to the ceaseless innovation driving the field of analytical chemistry forward. Since its nascent stages, SPE technology has undergone a transformative journey, marked by several pivotal milestones that have not only redefined the landscape of sample preparation but also propelled the discipline to

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Origins of SPE technology

Solid Phase Extraction (SPE) technology traces its roots back to the mid-20th century, with early developments in chromatography laying the groundwork for its evolution. The concept of using solid sorbents to selectively extract and purify analytes from solution can be traced back to the pioneering work of researchers in the field of chromatography and sample

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Two pots of SPE materials. C18 and HLB. At Poseidon-Scientific

Comprehensive Overview of Solid Phase Extraction (SPE) Technology

Solid Phase Extraction (SPE) technology is a prevalent sample preparation technique in analytical chemistry, utilized for isolating, purifying, and concentrating target analytes from complex sample matrices. SPE relies on the selective retention of analytes by a solid sorbent phase, while undesired matrix components are washed away. This process facilitates the production of cleaner extracts with

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Lots of HLB Spe Cartridges from Poseidon Scientific

“Unlocking Analytical Potential: The Indispensable Role of Solid Phase Extraction (SPE) Cartridges”

“Solid Phase Extraction (SPE) cartridges are indispensable tools in the realm of analytical chemistry, crucial for optimizing the efficiency, precision, and dependability of analytical methodologies. Below are elucidated some fundamental rationales delineating the pivotal role of SPE cartridges in this domain:” 1.Sample Cleanup and Pre-concentration–Enhanced Sensitivity and Detection Limits: “SPE cartridges serve a dual purpose

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