Environmental lab monitoring pharmaceutical contamination in water using SPE

Detecting Pharmaceutical Residues in Drinking Water with HLB SPE

Trace Pharmaceuticals in Drinking Water Pharmaceutical residues in drinking water represent a growing concern for environmental regulators and public health officials worldwide. Even at trace levels (ng/L to µg/L), compounds such as antibiotics, hormones, and analgesics can pose ecological risks and potential human health effects. The challenge lies in their low concentrations and the complexity […]

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SPE cartridge method used to clean grain extracts for mycotoxin detection

Extraction of Mycotoxins from Grain Samples Using SPE Cleanup

Why Mycotoxin Cleanup Matters in Grain Analysis Mycotoxins are toxic secondary metabolites produced by fungi such as Aspergillus, Penicillium, and Fusarium species. Common mycotoxins in grains include aflatoxins, ochratoxin A, deoxynivalenol (DON), zearalenone, and fumonisins. These contaminants pose serious health risks and are regulated by agencies such as the FDA and EFSA. Accurate detection requires

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Clinical lab extraction of steroid hormones from serum using SPE

SPE Sample Preparation for Steroid Hormone Analysis in Serum

Analytical Challenges for Steroid Hormones Steroid hormones in serum present a unique set of analytical hurdles. Their low circulating concentrations (often in ng/mL or pg/mL), combined with a complex biological matrix rich in proteins, lipids, and salts, demand highly selective sample preparation. Additionally, steroids vary in polarity—from hydrophobic androgens like testosterone to more polar corticosteroids—requiring

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Environmental laboratory analyzing pesticide residues in water using SPE

Monitoring Pesticide Degradation Products in Surface Water Using SPE

Introduction Pesticide degradation products, often referred to as metabolites or transformation products, are increasingly recognized as critical environmental contaminants. While parent pesticides are routinely monitored, many degradation products exhibit higher mobility, persistence, and in some cases, greater toxicity than their precursors. Monitoring these compounds in surface water is essential for a comprehensive risk assessment of

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Laboratory sample preparation for food preservative testing using SPE

SPE Workflow for Detecting Food Preservatives in Processed Foods

Introduction Food preservatives such as benzoates and sorbates are widely used to inhibit microbial growth in processed foods. Reliable detection of these preservatives is essential for regulatory compliance and quality control. Solid-phase extraction (SPE) provides a robust cleanup and preconcentration step before chromatographic analysis. This blog outlines a streamlined SPE workflow for detecting benzoic acid

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Clinical laboratory extraction of urine metabolites using WAX SPE cartridges

Using WAX SPE to Detect Organic Acid Metabolites in Urine

Why Profile Organic Acid Metabolites in Urine? Organic acid metabolites are intermediates of amino acid, fatty acid, and carbohydrate metabolism, and their urinary levels serve as critical biomarkers for inherited metabolic disorders, mitochondrial dysfunction, and nutritional status. Accurate profiling using weak anion exchange (WAX) SPE enables sensitive, selective detection of these acidic compounds. Characteristics of

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Laboratory extraction of veterinary drug residues from milk using HLB SPE

Extraction of Veterinary Drug Residues from Milk Using HLB SPE

Extraction of Veterinary Drug Residues from Milk Using HLB SPE 1. Regulatory Importance of Veterinary Drug Monitoring Veterinary drugs are widely used in dairy production to prevent and treat diseases, but their residues in milk pose potential health risks to consumers, including allergic reactions, antimicrobial resistance, and endocrine disruption. Regulatory agencies such as the FDA,

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SPE cartridge method used to isolate alkaloids from herbal medicine extracts

Developing an SPE Cleanup Protocol for Herbal Medicine Alkaloids

Herbal Matrices: A Unique Analytical Challenge Herbal medicines contain complex chemical mixtures, including alkaloids, flavonoids, tannins, pigments, and other secondary metabolites. This complexity poses significant challenges for targeted analysis. The matrix effect in LC-MS can suppress or enhance ionization of target analytes, leading to inaccurate quantification. Developing a robust solid-phase extraction (SPE) cleanup protocol is

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Laboratory SPE workflow used for PFAS environmental testing

Sample Preparation Strategy for PFAS Analysis Using SPE Cartridges

Introduction to PFAS Contamination Issues Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals widely used in industrial and consumer products due to their unique water- and oil-repellent properties. However, their extreme persistence in the environment and potential adverse health effects—including immune suppression, thyroid disruption, and certain cancers—have made them a top priority

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Laboratory workflow extracting artificial sweeteners from wastewater with HLB SPE

Using HLB SPE to Monitor Artificial Sweeteners in Wastewater

Environmental Occurrence of Artificial Sweeteners Artificial sweeteners, such as sucralose, acesulfame-K, and saccharin, are widely used as sugar substitutes in food, beverages, and pharmaceuticals. Due to their high water solubility, chemical stability, and resistance to biodegradation, these compounds pass largely unchanged through wastewater treatment plants and have been detected in surface waters, groundwater, and even

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