Understanding SPE Breakthrough: The Critical Phenomenon in Solid-Phase Extraction Solid-phase extraction (SPE) breakthrough represents one of the most significant challenges in analytical sample preparation, directly impacting method accuracy, precision, and overall analytical performance. As product manager at Poseidon Scientific, I’ve witnessed how breakthrough issues can compromise entire analytical workflows, leading to false negatives, inaccurate quantitation, […]

Common Causes of Low Recovery in SPE Low recovery in solid phase extraction (SPE) is one of the most frustrating challenges analytical chemists face. When your target analytes fail to appear in expected concentrations, it’s essential to systematically identify where the problem lies. According to forensic science literature, recovery problems in SPE can be categorized