What is Channeling in SPE Cartridges? Channeling in solid phase extraction (SPE) cartridges refers to the formation of tunnels or pathways through the sorbent bed where liquids flow preferentially, bypassing the majority of the stationary phase. This phenomenon occurs when excessive vacuum or pressure is applied during conditioning or sample loading steps, causing liquids to

Understanding SPE Breakthrough: The Critical Phenomenon in Solid-Phase Extraction Solid-phase extraction (SPE) breakthrough represents one of the most significant challenges in analytical sample preparation, directly impacting method accuracy, precision, and overall analytical performance. As product manager at Poseidon Scientific, I’ve witnessed how breakthrough issues can compromise entire analytical workflows, leading to false negatives, inaccurate quantitation,

Common Causes of Low Recovery in SPE Low recovery in solid phase extraction (SPE) is one of the most frustrating challenges analytical chemists face. When your target analytes fail to appear in expected concentrations, it’s essential to systematically identify where the problem lies. According to forensic science literature, recovery problems in SPE can be categorized