Applications

laboratory extraction of sunscreen chemicals from seawater using HLB SPE

HLB SPE Workflow for Monitoring UV Filters in Coastal Seawater

Introduction UV filters from sunscreens and personal care products are emerging contaminants in coastal environments. Their continuous input through recreational activities and wastewater discharge has raised concerns about ecological and human health effects. This workflow describes a robust analytical method using HLB SPE cartridges for the extraction and quantification of common UV filters, oxybenzone (benzophenone-3) […]

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clinical laboratory SPE extraction of beta blocker drugs from plasma

Developing an MCX SPE Method for Beta-Blocker Analysis in Plasma

1. Overview of Beta-Blocker Drugs and Pharmacokinetic Monitoring Beta-blockers (e.g., propranolol, metoprolol, atenolol) are widely prescribed for hypertension, angina, and arrhythmias. Therapeutic drug monitoring (TDM) in plasma is essential to ensure efficacy and avoid toxicity, requiring robust cleanup methods for accurate LC-MS/MS analysis. 2. Chemical Properties of Beta-Blockers as Basic Compounds Most beta-blockers contain secondary

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laboratory SPE extraction of NSAID pharmaceuticals from river water samples

Optimizing WAX SPE for the Extraction of NSAIDs from River Water

Environmental Relevance of NSAIDs in Aquatic Systems Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, diclofenac, and naproxen are among the most commonly detected pharmaceuticals in surface waters worldwide. These compounds enter aquatic environments primarily through wastewater effluent, agricultural runoff, and improper disposal. Even at trace concentrations (ng/L to µg/L), NSAIDs can cause adverse effects on

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Laboratory SPE extraction of amino acids from biological samples for analysis

Extraction of Amino Acids from Biological Samples Using SPE

Amino acid profiling has become a cornerstone of metabolomics, clinical diagnostics, and nutritional research. The quantitative analysis of free amino acids in biological fluids enables researchers to investigate metabolic disorders, monitor disease progression, and evaluate therapeutic interventions. Solid-phase extraction (SPE) is the preferred sample preparation technique due to its ability to clean up complex matrices

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Laboratory SPE extraction used for cosmetic preservative analysis

SPE Cleanup of Cosmetic Products Prior to Preservative Analysis

Cosmetic products present a significant analytical challenge due to their complex formulations containing oils, surfactants, fragrances, pigments, and active ingredients. These matrices can severely interfere with the accurate quantification of preservatives such as parabens, phenoxyethanol, formaldehyde releasers, and isothiazolinones. Solid-phase extraction (SPE) provides an effective cleanup strategy to isolate target preservatives while removing interfering components,

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Laboratory SPE extraction used for monitoring illicit drugs in wastewater

Detecting Illicit Drugs in Wastewater Using SPE Monitoring

Wastewater Epidemiology: A Window into Community Drug Use Wastewater-based epidemiology (WBE) has emerged as a powerful, non-invasive tool for monitoring community-level consumption of illicit drugs and pharmaceuticals. By analyzing specific biomarkers—typically drug metabolites excreted in urine—in influent wastewater, researchers can estimate drug use trends in near real-time. This approach complements traditional survey methods, offering objective,

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Laboratory SPE extraction of phenolic compounds from plant samples

SPE Extraction of Phenolic Compounds from Plant Extracts

The Challenge of Phenolic Compounds in Plant Extracts Phenolic compounds are secondary metabolites widely distributed in plants, recognized for their antioxidant, anti-inflammatory, and antimicrobial properties. They play critical roles in human health, contributing to the prevention of cardiovascular diseases, cancers, and neurodegenerative disorders. However, their extraction from complex plant matrices—which contain sugars, organic acids, pigments,

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Biomedical laboratory SPE extraction of metabolites from cell culture samples

Extraction of Metabolites from Cell Culture Media Using SPE

The Critical Role of Metabolomics in Cell Culture Research Metabolomics provides a functional readout of cellular states by profiling small-molecule metabolites in biological systems. In cell culture studies, analyzing the metabolome from conditioned media offers non-invasive access to extracellular metabolic activity, drug metabolism, and biomarker discovery. However, the complex matrix of cell culture media—rich in

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Laboratory SPE cleanup used to analyze colorants in beverage products

SPE Cleanup Method for Detecting Colorants in Beverage Products

Types of Synthetic Food Colorants Synthetic food colorants are widely used in beverages to enhance visual appeal and ensure product consistency. Common examples include Tartrazine (E102), Sunset Yellow (E110), Allura Red (E129), Brilliant Blue (E133), and Ponceau 4R (E124). These azo dyes and triarylmethane compounds are regulated by agencies like the FDA and EFSA, with

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Laboratory SPE extraction of endocrine disrupting chemicals from water

SPE Strategy for Monitoring Hormone Disruptors in Environmental Samples

Overview of Endocrine Disrupting Chemicals Endocrine disrupting chemicals (EDCs) are exogenous compounds that interfere with the endocrine system, leading to adverse health effects in humans and wildlife. They include natural hormones like estrogens, synthetic compounds such as bisphenol A (BPA), phthalates, and persistent organic pollutants (POPs). The European Commission defines EDCs as substances that alter

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