Applications

SPE cartridge concentrating trace contaminants from environmental water samples

Using SPE to Concentrate Trace Contaminants in Environmental Samples

Environmental Contaminants Monitored at Trace Levels Environmental monitoring programs routinely target contaminants at part-per-billion (ppb) and part-per-trillion (ppt) concentrations. These trace-level pollutants include pesticides (triazines, organophosphates, carbamates), pharmaceuticals, industrial chemicals (PCBs, PAHs, phenols), endocrine disruptors, and heavy metals. The challenge for analytical chemists is that these compounds exist at concentrations far below the detection limits […]

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SPE extraction of hormone compounds from blood plasma samples

SPE Sample Preparation for Hormone Analysis in Blood Plasma

1. Hormones Commonly Measured in Plasma Steroid hormone analysis in blood plasma encompasses a wide range of clinically relevant compounds that serve as biomarkers for endocrine function, reproductive health, and metabolic disorders. The most frequently measured steroid hormones include: Androgens Testosterone (free and total) Dihydrotestosterone (DHT) Androstenedione Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) Estrogens Estradiol

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SPE extraction workflow for multi residue pesticide testing

Designing SPE Workflows for Multi-Residue Pesticide Screening

Requirements for Multi-Residue Pesticide Analysis Multi-residue pesticide screening represents one of the most challenging analytical tasks in environmental and food safety testing. According to established literature, comprehensive screening workflows must address several critical requirements simultaneously. The primary objective is to detect and quantify a broad spectrum of pesticide residues at trace levels, typically in the

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SPE cartridge extracting drug metabolites from urine samples

SPE Cleanup of Urine Samples for Drug Metabolite Analysis

Drug Metabolites Commonly Detected in Urine Urine serves as the primary excretion pathway for drug metabolites, making it the matrix of choice for forensic toxicology, clinical monitoring, and doping control. The metabolites detected span various drug classes, each presenting unique chemical properties that influence extraction strategies. Common metabolites include benzoylecgonine (cocaine metabolite), norcodeine and normorphine

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SPE cartridge extraction of pesticide residues from drinking water samples

SPE Strategies for Sample Preparation of Pesticides in Drinking Water

Regulatory Limits for Pesticides in Drinking Water Drinking water safety is governed by stringent regulatory frameworks worldwide, with pesticide monitoring being a critical component of water quality assessment. The U.S. Environmental Protection Agency (EPA) establishes Maximum Contaminant Levels (MCLs) for specific pesticides in drinking water under the Safe Drinking Water Act. These limits are typically

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SPE cartridge cleanup of serum samples in clinical LC-MS laboratory

Best Practices for SPE Cleanup of Serum Samples in Clinical LC-MS Analysis

Common Clinical Analytes Measured by LC-MS Liquid chromatography-mass spectrometry (LC-MS) has revolutionized clinical analysis by enabling sensitive and specific detection of diverse analytes in serum samples. The technique’s versatility allows for comprehensive profiling across multiple therapeutic and diagnostic categories. Pharmaceutical Compounds LC-MS excels in therapeutic drug monitoring (TDM) for medications with narrow therapeutic windows. Common

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laboratory SPE extraction workflow analyzing antibiotic residues in milk samples

SPE Workflow for Antibiotic Residue Analysis in Milk Samples

1. Common Antibiotics Monitored in Dairy Testing Dairy product safety requires rigorous monitoring of antibiotic residues, with beta-lactams and tetracyclines being the most frequently analyzed classes. Beta-lactams, including penicillins (amoxicillin, ampicillin) and cephalosporins, are widely used in veterinary medicine for treating mastitis and other infections. Tetracyclines such as oxytetracycline, tetracycline, and chlortetracycline are broad-spectrum antibiotics

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SPE cartridge extracting antibiotic residues from honey sample

SPE Method for Extraction of Veterinary Antibiotics from Honey

Honey Matrix Challenges Including High Sugar Content Honey presents unique analytical challenges for veterinary antibiotic residue analysis due to its complex matrix composition. As a natural product with approximately 80% sugar content (primarily fructose and glucose), honey creates significant interference issues for analytical methods. The high viscosity and sugar concentration can lead to: Column fouling

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SPE cartridge extracting organic acids from fermented food sample

Laboratory Workflow for SPE Extraction of Organic Acids in Fermented Foods

Fermented Food Matrices and Organic Acid Composition Fermented foods represent a diverse category of complex matrices that include dairy products (yogurt, cheese), vegetables (sauerkraut, kimchi), beverages (wine, beer), and soy products (miso, tempeh). These foods undergo microbial transformation where organic acids play crucial roles in flavor development, preservation, and nutritional quality. The primary organic acids

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SPE cartridge extracting endocrine disrupting compounds from water sample

SPE Sample Preparation for LC-MS Detection of Endocrine Disruptors in Water

1. Overview of Endocrine Disrupting Compounds in Water Endocrine disrupting compounds (EDCs) represent a significant environmental concern due to their ability to interfere with hormonal systems at trace concentrations. These compounds include diverse chemical classes such as bisphenols (notably bisphenol A), natural and synthetic hormones (estrogens, androgens), pharmaceuticals, pesticides, and industrial chemicals. According to research,

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